NIREN ANGLE, MD, RVT, FACS
Phone: Office: (619)543-6980
Current position: Associate Professor of Surgery In-Residence,
Vascular and Endovascular Surgery,
UCSD Department of Surgery,
San Diego, California
Attending Staff Surgeon,
UCSD Medical Center, San Diego, California
Attending Staff Surgeon,
VA Hospital, La Jolla, California
Previous Positions: Assistant Professor In-Residence,
Attending Staff Surgeon,
Division of Vascular Surgery
Department of Surgery,
UCLA Medical Center, Los Angeles, California
Attending Staff Surgeon
UCLA Santa Monica Hospital
Attending Staff Surgeon
Oliveview-Los Angeles County Hospital
EDUCATION
High School: Cathedral High School, Chicago, IL 1980-1984
Undergraduate: San Jose State University, San Jose, CA 1984-1988
Graduate: Loyola University of Chicago Stritch 1988-1992
School of Medicine, Chicago, IL
Post-graduate: Internship, General Surgery 1992-1993
University of California, San Diego Medical Center
Assistant Resident, General Surgery 1993-1995
University of California, San Diego Medical Center
Surgical Research Fellow 1995-1997
Surgical Immunology, Division of Trauma,
University of California, San Diego Medical Center
Senior Resident, General Surgery 1997- 1998
University of California, San Diego Medical Center
Chief Resident, General Surgery 1998-1999
University of California, San Diego Medical Center
Fellowship Vascular Surgery Fellow (Research) 1999- 2000
University of California, Los Angeles
UCLA Gonda Vascular Center
Clinical Fellow, Vascular Surgery 2000-2001
University of California, Los Angeles
UCLA Gonda Vascular Center
DEGREES
Bachelor of Arts, Biological Sciences, with minor in Humanities,
San Jose State University, San Jose, CA 1988
Doctor of Medicine
Loyola University of Chicago Stritch School of Medicine 1992
Surgical Internship Completion Certificate
University of California, San Diego 1993
Captain, United States Air Force Reserve, MC 1996
Major, United States Air Force Reserve, MC 2003
General Surgery Residency Completion Certificate 1999
University of California, San Diego
Vascular Surgery Fellowship Completion Certificate 2001
University of California, Los Angeles
LICENSURE / CERTIFICATION
Passage of the National Board of Medical Examiners’ Examinations
Part I (1986), Part II (1988), Part III (1992)
Current Medical License, State of California
Current Drug Enforcement Administration Certificate
Current ATLS certification
Current ACLS provider certification
American Board of Surgery Certification in General Surgery (2000)
American Board of Surgery Certification in Vascular Surgery (2002)
RVT (Registered Vascular Technologist), American Registry For Diagnostic Medical Sonography (2005)
POSITIONS
Coordinator, UCSD General Surgery Basic Science Weekly Conference 1995 - 1998
Coordinator, UCSD General Surgery Journal Club 1995 - 1998
Coordinator, UCLA Vascular Surgery Journal Club 2000 - 2001
Basic Science Curriculum Coordinator, 2005 - present
UCSD General Surgery Residency Curriculum Conference
Member, UCSD Medical Group Board of Governors 2005 - present
COMMITTEES
UCLA-Santa Monica Pharmacy, Nutrition, and Therapeutics Committee 2001 - 2002
UCLA-Santa Monica Infection Control Committee 2001- 2002
UCLA-Santa Monica Wound Care Committee 2001- 2002
UCLA-Santa Monica Surgery Case Review Committee 2001 - 2002
UCSD Pharmacy and Therapeutics Committee 2003 - 2004
UCSD Infection Control Committee 2003 – present
UCSD Perioperative Services Executive Committee 2005 – present
UCSD Operating Room Block Time Subcommittee 2005 - present
UCSD Cardiovascular Center Expansion Surgery Workgroup 2005 - present
PROFESSIONAL MEMBERSHIPS
Association of Academic Surgery 1995 - present
Society of Critical Care Medicine 1994 - 2004
American College of Surgeons, Associate Fellow 1996 – 2004
American College of Surgeons, Fellow 2004 - present
American College of Surgeons, Southern California Chapter 2002 - present
Peripheral Vascular Surgery Society 2002 - present
American Heart Association 2002 – present
European Society for Vascular Surgery 2003 - present
American Stroke Association 2003 – present
American Association for the Advancement of Science 2004 – present
Southern California Vascular Surgery Society 2004 – present
Western Vascular Society 2004 – present
Society for Vascular Surgery 2004 – present
International Academy of Applied Thrombosis/Hemostasis 2004 - present
International Society for Vascular Surgery 2004 – present
International Society of Endovascular Specialists 2004 – present
Society for Vascular Ultrasound 2004 – present
Society for Vascular Surgery 2004 – present
San Diego County Medical Society 2005 – present
California Medical Association 2005 – present
American Diabetes Association 2005 - present
UCSD Clinical Investigation Institute Membership 2005 - present
AD HOC REVIEWER
Venous Digest
Archives of Surgery
PRESENTATIONS
American College of Surgeons Clinical Congress, Owen Wangensteen Surgical Forum 1996, San Francisco, CA
American College of Surgeons, Committee on Trauma (ACS-COT) Residents’ Papers Competition, Region IX, 1996-1997, Los Angeles, CA
American College of Surgeons, Committee on Trauma (ACS-COT) Residents’ Papers Competition, National Competition, 1996-1997, Santa Fe, NM
SHOCK Society, 20th Annual Conference on Shock, 1997, Indian Wells, CA
American Association for the Surgery of Trauma (AAST), 57th Annual Meeting, AAST and Japanese Association for Acute Medicine, 1997, Waikaloa, HI
American College of Surgeons Clinical Congress, Owen Wangensteen Surgical Forum 1997, Chicago, IL
American College of Surgeons, Committee on Trauma (ACS-COT) Residents’ Papers Competition, Region IX, 1997-1998, Los Angeles, CA
UCSD Nursing Neurotrauma Conference, Penetrating Trauma: Diagnosis, management, and pitfalls, 1998, San Diego, CA
American College of Surgeons, Committee on Trauma (ACS-COT) Residents’ Papers Competition, Region IX, 1998-1999, San Francisco, CA
Peripheral Vascular Surgery Society 25th Annual Spring Meeting, 2000, Toronto, Canada
Association for Academic Surgery Annual Meeting - 2000, Tampa, FL
Southern California Chapter of the American College of Surgeons, 2001, Santa Barbara, CA
Southern California Vascular Surgery Society Meeting 2001, Santa Barbara, CA
American Lung Association’s Better Breathers’ Club, May 2001, Los Angeles, CA
Association of VA Surgeons Annual Meeting 2001, Atlanta, GA
UCLA Vascular Surgery Nursing Symposium, June 2001, Los Angeles, CA
UCLA Primary Care Network CME Presentation, June 2002, Los Angeles, CA
Western Vascular Society 17th Annual Meeting, Open versus Endovascular repair of abdominal aortic aneurysm: What do they really cost? September 2002, Newport Beach, CA
UCSD Department of Medicine Grand Rounds: Carotid Endarterectomy for Prevention of Stroke: Risks, Stratification, and Management in 2003, April 2003, San Diego, CA
Society of General Surgeons in San Diego: New Horizons for Carotid Intervention. February 2004, San Diego, CA
San Diego Postgraduate Assembly in Surgery, 27th Annual Conference, Modern Approach to Dialysis Access Surgery. February 2004, San Diego, CA
San Diego Postgraduate Assembly in Surgery, 27th Annual Conference, Carotid Endarterectomy vs. Carotid Angioplasty/Stenting – Is there Clinical Equipoise? February 2004, San Diego, CA
UCSD Annual Nursing Critical Care Conference, Summer Session, Vascular Emergencies. July 2004, San Diego, CA
San Diego Postgraduate Assembly in Surgery, 28th Annual Conference, Modern Methods in Dialysis Access. February 2005, San Diego, CA
San Diego Postgraduate Assembly in Surgery, 28th Annual Conference, Chronic Mesenteric Arterial Ischemia. February 2005, San Diego, CA
Association for Academic Surgery Annual Meeting, VEGF Inhibits PDGF stimulated Calcium signaling Independent of Phospholipase C and Protein Kinase C Activation, Houston 2004
Southern California Chapter of the American College of Surgeons Annual Meeting. The Occluded Graft: a potentially limb-threatening entity, Santa Barbara, 2004
Western Vascular Society Annual Meeting, PDGF inhibits PDGF stimulated calcium release and MAPK activation in vascular smooth muscle cells, Victoria, British Columbia 2004
Society of University Surgeons, Vascular Endothelial Growth Factor Stimulates a Novel Calcium Signaling Pathway in Vascular Smooth Muscle Cells, St.Louis, MO 2005
2005 Joan L. and Julius H. Jacobson Research Initiatives in Vascular Disease Conference, sponsored by SVS & NIH, Vascular Endothelial Growth Factor Stimulates Differential Signaling Pathways in Vascular Endothelial Cells and Vascular Smooth Muscle Cells, Bethesda MD, 2005
AWARDS
Best Basic Science Paper, Region IX, American College of Surgeons, Committee on Trauma (ACS-COT) Scientific Papers Competition, Residents’ Competition, 1996-97
Outstanding Teaching Award - Chief Resident, 1999
Chairman’s Prize, UCSD Department of Surgery - Chief Resident, 1999
RESEARCH GRANTS
UCSD Academic Senate Grant 01/01/04 – 12/31/04
Title: The role of VEGF in endothelial-smooth muscle function and response to injury.
UCSD Academic Senate Grant 01/01/06 – 12/31/06
Title: The role of VEGF in limb-ischemia and reperfusion injury
ONGOING RETROSPECTIVE CLINICAL STUDIES
Renal artery stenosis: Management and outcomes at a university center over 20 years
Project #051089 Approved 09/01/05
Carotid Dissection: Presentation and management
Project #050062 Approved 01/06/05
Acute limb ischemia: Trends in management and associated outcomes
Project #040769 Approved 05/28/04
Renal artery stenosis: Management and outcomes at a university center over 20 years
Project #030633 Approved 04/22/04
Aortic dissection: Management and outcomes at a university center over 20 years
Project #030632 Approved 05/20/04
MANUSCRIPTS
Peer-Reviewed Publications
1. Angle N, Coimbra R, Hoyt DB, et al.: Hypertonic saline resuscitation prevents lung injury following hemorrhagic shock. Surgical Forum 47: 43-45, 1996
2. Angle N, Hoyt DB, Cabello-Passini R, et al.: Hypertonic saline resuscitation suppresses neutrophil margination by reducing neutrophil L-selectin expression (Abstract). Journal of Trauma 43: 204, 1997
3. Angle N, Hoyt DB, Junger WG, et al.: Hypertonic saline resuscitation diminishes neutrophil activation following hemorrhage. (Abstract) Shock 7: Suppl.2, 47, 1997
4. Coimbra R, Hoyt DB, Junger WG, Angle N, et al.: Hypertonic saline decreases susceptibility to sepsis after hemorrhagic shock. Journal of Trauma 42: 602-608, 1997
5. Angle N, Hoyt DB, Cabello-Passini R, et al.: Hemorrhage primes alveolar macrophages for enhanced CINC release, irrespective of type of resuscitation fluid. Surgical Forum 48: 132-134, 1997
6. Angle N, Bergan JJ: Chronic venous ulcer. British Medical Journal 314: 1019-23, 1997
7. Coimbra R, Angle N, Da Silva L, et al.: Trauma Scores: What they are and why they should be used. Journal of the Brazilian College of Surgeons 24: 255-263, 1997
8. Coimbra RSM, Angle N, Silva LE, Hoyt DB, Rasslan S. Indices de Trauma: O que sao e por que devem ser usados. (Portugese) Rev Col Bras Cir 24:255-263, 1997
9. Angle N, Hoyt DB, Cabello-Passini R, et al.: Hypertonic saline resuscitation reduces neutrophil margination by suppressing neutrophil L-selectin expression. Journal of Trauma 45: 7-13, 1998
10. Angle N, Hoyt DB, Coimbra R, et al.: Hypertonic saline resuscitation diminishes lung injury by suppressing neutrophil activation following hemorrhagic shock. Shock 9: 164-170, 1998
11. Bergan J, Sparks S, Angle N: A comparison of compression pumps in the treatment of lymphedema. Vascular Surgery 32: 455-462, 1998
12. Angle, N, Coimbra R, Hoyt DB. Pitfalls in the management of the trauma patient in the ICU. Trauma 1(4):301-312, 1999
13. Angle N, Cabello-Passini R, Hoyt DB, et al.: Hypertonic saline infusion: Can it regulate human neutrophil function? Shock 14: 503-508, 2000
14. Angle N, Moore WS: Carotid endarterectomy without pre-operative angiography. Acta Chirurgica Belgica 100:185-189, 2000
15. Angle N, Gelabert HA, Farooq MM, et al.: Safety and efficacy of the early surgical decompression of the thoracic outlet for Paget-Schroetter syndrome. Annals of Vascular Surgery 15(1): 37-42, 2001
16. Pross C, Farooq MM, Angle N, et al.: Dexamethasone inhibits vascular smooth muscle cell migration via modulation of matrix metalloproteinase activity. Journal of Surgical Research 102(2):57-62, 2002
17. Pross C, Farooq MM, Lane JS, Angle N, et al.: Rat and human aortic smooth muscle cells display differing migration and matrix metalloproteinase activities in response to dexamethasone. Journal of Vascular Surgery 35(6): 1253-1259, 2002
18. Kansal N, LoGerfo FW, Belfield AK, Pomposelli FB, Hamdan AD, Angle N, Campbell DR, Sridhar A, Freischlag JA, Quinones-Baldrich W. A comparison of antegrade and retrograde mesenteric bypass. Annals of Vascular Surgery 16(5):591-596, 2002
19. Angle N, Dorafshar AH, Farooq MM, Ahn SS, et al.: The evolution of the axillo-femoral bypass over two decades. Annals of Vascular Surgery 16(6):742-745, 2002
20. Angle N, Dorafshar AH, Ahn SS. Mycotic Aneurysm of the Internal Carotid Artery. Vascular and Endovascular Surgery 37(3):213-217, 2003
21. Dorafshar AH, Angle N, Breyer-Ash M, et al. Vascular Endothelial Growth Factor Inhibits Mitogen Induced Vascular Smooth Muscle Cell Proliferation. Journal of Surgical Research 114(2): 179-186, 2003
22. Angle N, Dorafshar AH, Farooq MM, et al. Open versus endovascular repair of abdominal aortic aneurysms: what does each really cost? Annals of Vascular Surgery 18(5):612-618, 2004
23. Dorafshar AH, Reil TD, Moore WS, Quinones-Baldrich WJ, Angle N, et al. Cost analysis of carotid endarterectomy: is age a factor? Annals of Vascular Surgery 18(6): 729-735, 2004
24. Angle N, Chandra A, Badel P. VEGF inhibits PDGF-stimulated calcium signaling independent of phospholipase C and PKC activation. Journal of Surgical Research 121(2):289, 2004
25. Angle N. Invited Commentary on “Combination treatment of venous thoracic outlet syndrome: open surgical decompression and intraoperative angioplasty”. Venous Digest 12, January 2005
26. Angle N, Schneider PA. What are the skills that prepare vascular surgeons for carotid stenting? Perspectives in Vascular Surgery and Endovascular Therapy, Journal of Surgical Research, Epub July 2005
27. Angle N, Chandra A. The Two Stage Brachial Artery-Brachial Vein Autogenous Fistula for Hemodialysis: An alternative autogenous option for hemodialysis access. Journal of Vascular Surgery 42(4):806-10, 2005
28. Chandra A, Angle N. VEGF inhibits PDGF-stimulated calcium signaling independent of phospholipase C and protein kinase C. Journal of Surgical Research, July 2005
29. Chandra A, Angle N. VEGF stimulates a novel calcium signaling pathway in vascular smooth muscle cells. Surgery. Surgery 138(4):780-7, 2005
CHAPTERS
1. Angle N, Bergan JJ: Chronic venous insufficiency. In Moore WS (ed.):Vascular Surgery: A Comprehensive Review. Philadelphia, PA, W.B.Saunders, 1997
2. Bergan J, Angle N.: Venous thromboembolic disease: Clinical presentation, epidemiology and medical management. In Perler BA, Becker GJ (ed). Vascular Intervention: A Clinical Approach. New York, NY, Thieme Medical Publishers, 1998
3. Angle N, Freischlag JA. Reversed vein bypass. In Nyhus LM, Baker RJ, Fischer JE (eds): Mastery of Surgery. Little, Brown & Company, 2001.
4. Angle N, Freischlag JA. Prosthetic graft infections. In Moore WS (ed.): Vascular Surgery: A Comprehensive Review: Philadelphia, PA, W.B. Saunders, 2001
5. Angle N, Quinones-Baldrich W. Acute Arterial and Graft Occlusion. In Moore WS (ed.): Vascular Surgery: A Comprehensive Review: Philadelphia, PA, W.B. Saunders, 2001
6. Angle N, Kafie FE, Quinones-Baldrich W. Thrombolytic Therapy. In Moore WS (ed.): Vascular Surgery: A Comprehensive Review: Philadelphia, PA, W.B. Saunders, 2001
7. Angle N, Freischlag JA. Acute Lower Extremity Ischemia. In Lillemoe K, Schulick R (eds): Pocket General Surgery, PocketMedicine.com, Philadelphia, PA 2004
8. Angle N, Freischlag JA. Chronic Lower Extremity Ischemia. In Lillemoe K, Schulick R (eds): Pocket General Surgery, PocketMedicine.com, Philadelphia, PA 2004
9. Angle N, Freischlag JA. Venous Disease. In Sabiston’s Textbook of Surgery 18th Ed., Philadelphia, PA, W.B. Saunders, 2004
10. Angle N, Freischlag JA. Prosthetic Graft Infections. In Moore WS (ed.): Vascular Surgery: A Comprehensive Review: Philadelphia, PA, W.B. Saunders, 2006
11. Angle N, Quinones-Baldrich W. Acute Arterial and Graft Occlusion. In Moore WS (ed.): Vascular Surgery: A Comprehensive Review: Philadelphia, PA, W.B. Saunders, 2006
12. Angle N, Quinones-Baldrich W. Thrombolytic Therapy. In Moore WS (ed.): Vascular Surgery: A Comprehensive Review: Philadelphia, PA, W.B. Saunders, 2006
13. Angle N. Diagnosis and Management of Primary Axillo-subclavian vein thrombosis. In The Vein Book, San Diego, CA, Elsevier Publishing, Submitted for publication
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